Power-Ups are featured in every Zombies map that help the player(s) in different ways. Power-Ups drop from Zombies, Hellhounds, the Pentagon Thief, Space Monkeys, Zombie Monkeys, the teleporters in Der Riese, the random teleporter rooms in Kino der Toten, George A. Romero, in between Gravity Lifts, from the Quantum Entanglement Device, adding points to the keys in the Bank, behind a door in the map Nuketown Zombies, Jumping Jacks, in certain prison cells in the map Mob of the Dead, Brutus or digging with the Shovel. Each Power-Up's icon is gold with a green glow (with the exception of the Death Machine, Zombie Blood and Lightning Bolt, which are silver and glow blue) and hover above the ground. The icon will blink when it is about to disappear (except on the Nintendo Wii version of Call of Duty: Black Ops, where it becomes more transparent until it disappears). All power-ups give off a whistling or humming noise when a zombie drops them. Also, the Demonic Announcer will announce they have been picked up by saying a phrase that varies depending on the power-up, with the exception of the Random Perk Bottle and Tombstone.
Power-Ups drop randomly from enemies in the Zombies mode, but only if the enemy is inside the map and not outside the barriers. Zombies have a chance to drop any Power-Up randomly except the Bonfire Sale, Random Perk Bottle, and Lightning Bolt (Fire Sale will only drop after the Mystery Box has moved at least once and Carpenter will only drop if five or more windows are destroyed). In some cases Power-Ups will be given from specific enemies, Max Ammo is guaranteed to drop from the last Hellhound, the Pentagon Thief, the last Space Monkey, the last Jumping Jack and the last Templar Zombie attacking a 115 Generator. If the Pentagon Thief is killed, he will drop a Fire Sale in addition to the Max Ammo. If he takes no weapons, he drops a Bonfire Sale in place of the Fire Sale. The Pack-a-Punch Machine will now be 1000 points (If Bonfire Sale is grabbed)
In Ascension, the Random Perk Bottle can be obtained if all monkeys during a monkey round are killed before any Perk-a-Cola machines have been attacked. In Call of the Dead, the player will receive the Death Machine or the Lightning Bolt (depending on whether or not they've completed the Original Characters Trapped Easter Egg) and the Random Perk Bottle for killing George A. Romero. In Shangri-La, Power-Ups can be stolen by Zombie Monkeys and turned into a different Power-Up if the monkey is killed before it returns to the Pack-a-Punch Machine. In Moon sometimes, Power-Ups float around the gravity lifts in the Biodome or a Bonus Points bonus may spawn from a Quantum Entanglement Device.
Power-Ups come in six colors. Green Power-Ups have passive effects on the player, Blue Power-Ups have an active effect, Red Power-Ups have a negative effect on the player or positive effects to zombies and negative effects to humans in Turned and Purple Power-Ups which only affect the zombies. Gold Power-Ups also have passive effects on a player. Silver Power-Ups do the same thing to gold, but less greater. Gold and silver will only appear on Dead Ops Arcade.
In Call of Duty: Black Ops (DS), Power-Ups are different; they are all made of the colors brown, white, bronze and silver, they have no glow to them, they are 2D icons, the player can only have one timed Power-Up at a time, and they can also be collected if they are attacked (for example, if a player threw a Throwing Knife at one).
- Main article: Insta-Kill
- "Man up Zombies, it's time to die!"
- — Tank Dempsey after getting Insta-Kill Nacht der Untoten, players are awarded 10 + 100 points for any kind of kills during the Insta-Kill duration, as opposed to the 130 for a knife kill, 60 for a torso kill and 50 for a limb kill they would normally get if Insta-Kill wasn't activated. In all Call of Duty: Black Ops maps the player will get 10 + [50/60/100/130] for [limb kill/torso kill/headshot/knife kill] respectively. It is recommended to only use a knife during the time that Insta-Kill is active to save ammo unless zombies are in a large horde. Also grenades become very useful as hitting a zombie with a grenade will kill it, and when the grenade explodes, it will kill all zombies in the blast radius. In Call of Duty: Black Ops II, if players do not get a kill during two consecutive Insta-Kills, they will be rewarded with Red Insta-Kill. It allows players to walk into zombies to kill them, however, the Red Insta-Kill lasts for half the time compared to a regular Insta-Kill
- Main article: Double Points
- "Double the honor!"
- — Takeo Masaki on Double Point's effect Ascension, if the rocket is destroyed a Double Points will drop below in the room before the Pack-a-Punch room.
When the Double Points power-up is active, hacking another player gives them 1000 points and still only deducts 500 from your score.
In the mode Turned, there will be a green Double Points, giving the human 20 points per second and double the points per kill; a red Double Points, which is picked up by a zombie that makes the other zombies lose 5 points every three seconds. There's also a blue double points, which can be picked up by any player. It will work the same way depending on what team you are on.
- Main article: Max Ammo
- "Why do I feel so heavy now?"
- — Nikolai Belinski after getting his ammo back Der Riese, Five, and Kino der Toten. If a player has put down two Bouncing Betties, and thus has none in their inventory, it will not give the player new Betties. However, if only one Betty has been put down, the player will get a second Betty. In Call of Duty: Black Ops, it will refill the player's inventory regardless of the number they currently have. Max Ammo is guaranteed to drop off of the last Hellhound of a Hellhound round, or the first zombie of the next round and the Pentagon Thief, regardless of whether or not he was defeated. Max Ammo also appears at the end of every Monkey round on Ascension whether they took perks or not.
- Main article: Nuke (Zombies)
- "Ka-fucking Boom meatsacks!"
- — Tank Dempsey following the nuke's carnage
- Main article: Carpenter
- "The stake that sticks out, gets hammered down."
- — Takeo Masaki activating Carpenter. Der Riese and has been present in all Zombie maps made afterwards, excluding Dead Ops Arcade, Nuketown, Mob of The Dead, Origins, and including the other Call of Duty: World at War maps in Call of Duty: Black Ops.
- Main article: Fire Sale
- "If this were Russia, it would be free. Just be polite."
- — Nikolai Belinski obtaining Fire Sale Mystery Box from 950 to 10 points for 20 seconds. It also makes the Mystery Box spawn at every possible point. A Fire Sale will not drop from Zombies if the Mystery Box has not been moved at least once. This Power-Up was introduced in Call of Duty: Black Ops. The icon is a large price tag that says "sale!!!". A 60's style rock 'n' roll song is played while the power-up is active, except for in Buried, where it plays a different jingle.
- Main article: Death Machine
- "This thing's bigger than me?"
- — Sarah Michelle Gellar getting a Death Machine Casimir Mechanism in Ascension or opening the M.P.D. in Richtofen's Grand Scheme). It has infinite ammo and can be a significant asset later in the round. The icon is similar to the icon for the Rapid Fire attachment. However, the player wielding it cannot revive players and Perk-a-Cola's cannot be purchased when the Power-Up is in use, although it is possible to rebuild barriers with the Power-Up active. The icon is five golden bullets. Instead of the green glow, the Death Machine Power-Up has a blue glow.
- Main article: Bonfire Sale "Five". It links all of the Teleporters to the Pack-a-Punch Machine, regardless of DEFCON level, and lowers the price of using it from 5000 points to 1000 points. The only way to get Bonfire Sale is to kill the Pentagon Thief before he steals anyone's weapons. The icon is a Pack-a-Punch Machine.
- Main article: Random Perk Bottle perk, it can be used to exceed the four perk limit. Appears in Ascension, Call of the Dead, Shangri-La, Moon, Die Rise and Buried. This Power-Up will drop in Ascension if the player successfully completes a monkey round without having any of the perk machines attacked by Space Monkeys. In Call of the Dead, the player must kill George A. Romero. In Shangri-La, it is only obtainable by killing the Zombie Monkey that steals a Max Ammo (it cycles through all Power-Ups, the bottle appears for 0.25 seconds). In Moon, it can be obtained by throwing a Quantum Entanglement Device near a Perk-A-Cola machine, occasionally a random perk will be given to the player. In Die Rise if the player defeats the Jumping Jacks on the special round with 100% accuracy, the last Jumping Jack will drop this Power-Up along with a Max Ammo. The icon is a bottle.
- Main article: Empty Perk Bottle
The Empty Perk Bottle is similar to the Random Perk Bottle, as it increases the amount of perks a player can purchase, by using either a Perk-a-Cola Machine or the Der Wunderfizz machine. If the player repeatedly does this, they will be able to obtain eight perks.
- Main article: Lightning Bolt
- "Lightning is power!"
- — Samantha on the Wunderwaffe DG-2 Only appears in Call of the Dead. Awarded when the player completes the Stand-in or Ensemble Cast Easter Egg. It grants the player a Wunderwaffe DG-2 that can't be Pack-a-Punched and will disappear when the player runs out of ammo (although Max Ammo refills it). It will also be dropped by George A. Romero upon death from then on. The icon of the power-up is the same icon as a Death Machine.
- — Samantha Maxis, when the weapon is picked up.Only appears in Moon and Origins. In Moon, the player must throw a Quantum Entanglement Device. When thrown, it may drop a random weapon, Pack-a-Punched or not. Picking up the Power-Up instantly replaces the players weapon with the one in the Power-up. In Origins, the player has to complete a challenge by Performing 115 Normal Zombie Headshots, and it will give one of a selection of Pack-a-Punched weapons.
- Main article: Bonus Points (Power-Up)
- "Points for everybody!"
- — Takeo Masaki after getting bonus points
Only appears in Moon, Dead Ops Arcade, TranZit, and Buried. In Moon, it only appears after the player has thrown a QED. The effect is random; it gives the player who picks it up (or everyone in the game) a random number of points. The power-up looks like a Z with two lines going across it, like a $ sign. It's model is based on a regular treasure in Dead Ops Arcade. In Call of Duty: Black Ops II, in TranZit in Green Run, at the location Town, the Bonus Points can appear in the bank. After melee attacking the two keys, with Galvaknuckles, every 1100 points you deposit, the drop appears and the other player will get 1000 per 1100 the other player added (not doubled with Double Points). This also applies for Buried because the bank is there also.
- Main article: Blood Money
In Origins, Blood Money is obtained through digging it up. It looks and has a similar function to Bonus Points, as it gives the player a random amount of points ranging from 25 to 500 points when obtained. If the player kills zombies near a Blood Money power-up it will result in the player getting more points from it. This power-up is affected by Double Points.
Anti-Power-Ups only appear in Moon and Diner Turned and are "negative power-ups". They appear only after using a QED in Moon, and at random on Diner Turned, and look like a normal power-up except with a red aura instead of a green one similar to the power-ups in Shangri-La when the monkey is randomizing it. Only zombies are able to grab these. Known Anti-Power-Ups include:
- Anti-Max Ammo: Removes all players' reserve ammunition, or in Turned, empties the clip of the player's gun.
- Anti-Perk Reward: Removes a Perk from every player, or spawns the first survivor in Turned.
- Anti-Bonus Points: Removes a random amount of points from all players.
- Anti-Fire Sale: Spawns the Mystery Box far from the player's location and doubles the cost to 1900 points.
- Anti-Insta kill: Zombies will down a player in one hit whether the player has Juggernog or not. However, this is a rare occurrence.
- Anti-Nuke: Only in Turned, the zombie who grabs it will kill the live human and become the survivor.
- Anti-Double Points: Only in Turned, zombies earn a double points bonus.
- Main article: Zombie Flesh The Zombie Flesh power-up is only available in the Call of Duty: Black Ops II game mode Grief. It was first revealed in Delivery 7 on the Call of Duty official website. This power-up gives the player a piece of meat which can be thrown anywhere in the map. It lures the zombies towards it and they stop and stand near it. It can be stuck to a person, luring zombies to that person. If it is thrown outside of the map, the zombies will be unaffected by it and continue to attack the player. It emits a green aura.
This power-up can only be obtained in Origins, by killing 20 Templar zombies with the Thunder Fists at the excavation site. It gives the player an upgraded version of the Thunder Fists that can take on the elemental powers of any staff currently equipped.
This power-up can only be obtained in Turned mode, at the start of the game in the middle of the map. It will only spawn once at the beginning of every game. It shares the same drop as random perk bottle except it's red. Upon being picked up by a player, the player who picked it up will become the survivor.
Full Reload functions similarly to Max Ammo, and will refill all players' ammunition when picked up.
Hyper-Damage functions similarly to Insta-Kill, and will allow players to kill zombies in one hit, during 30 seconds.
DNA Bomb functions similarly to the Nuke power-up, and will kill every zombie on the map in a green flash.
Security, while active, will activate all traps on the map during 30 seconds.
Multiplier functions like Double Points, giving the player twice as many points as usual, including from terminals, during 30 seconds.
Power Surge functions like Fire Sale, and will make every 3D Printer on the map function, costing only 10 credits per use, during 30 seconds.
Resupply is a power-up that is dropped by players upon death, and that can be picked up only by the player who dropped it. When picked up, the player will recover one of their weapons they had before dying.
- In the original version of Nacht der Untoten, power-ups showed how much time they had left on screen, but it was changed to an icon which blinked depending on how much time is left.
- In Moon, various power-ups may be hacked with the Hacker to change them into Max Ammo. Max Ammo can be hacked into Fire Sale for 5000 points.
- On Moon, power-ups can spawn in the Biodome around any Gravity Lift.
- In Nuketown Zombies, a power-up will randomly spawn in the shed of the yellow house. This power up will change every time the 'Nuke Clock' ticks over (Every 100 Kills marked on the Nuketown sign)
- The insta-kill will not give a 10 point bonus per kill if the weapon used to kill the zombie would have been an instant kill anyway.
- In Turned, a purple power-up will sometimes spawn. This means the power-up is available to the first person to grab it, the human or the zombies.
- A green glow means that all players get the power-up, Blue glow means that only player who picked up power-up gets it.
- When a Monkey Zombie from the map Shangri-La picks up a perk, the perks that it cycles through vary in how long it appears on the monkey's back; for instance a Random Perk Bottle or a Max Ammo will not last as long as a Carpenter or an Insta-Kill.