Safeguard can refer to:
- Safeguard (Soundtrack) - The fourteenth song in the Call of Duty: Modern Warfare 2 Soundtrack.
- Safeguard (game mode) - A game mode similar to Survival Mode in Call of Duty: Ghosts.
- Safeguard (Achievement) - An achievement in Call of Duty: Ghosts for the aforementioned game mode.
- Safeguard (Black Ops III) - A game mode set to appear in Call of Duty: Black Ops III.