Samantha Maxis was born to Ludvig Maxis and his unknown wife. After his wife died, Maxis made sure she was always close to him. Due to his research, however, he neglected her and failed to notice Richtofen's experiments on her. As the experiments went on, Richtofen grew to hate her, perhaps due to Maxis' attachment to her or due to what she had become. When Richtofen trapped Sam in the room with Fluffy and activated the teleporter, she was teleported to Griffin Station. There in a panic she accidentally came in contact with the M.P.D. and took control of the zombies. In an effort to stop her and free her so that Richtofen could operate it, Groph and Schuster found and brought Maxis to her. However, Maxis told her to kill them all and disappeared, sending Samantha over the edge and on a rampage to destroy all of Group 935, which had betrayed Maxis. After Richtofen trades bodies with her to control the zombies, she and the super soldier test subjects activate Maxis's backup plan and incinerate the earth, leaving Richtofen trapped in her body and able to control the Zombies on the Moon and the remaining Zombies on Earth.
Richtofen often references her in Call of Duty: Black Ops II, claiming that she cheated when she was in control of the zombies.
Samantha's voice is reused for the Demonic Announcer in Mob of the Dead, but it is unlikely to be her as it takes place many years before she is sent to the MPD (like in Nacht Der Untoten). The new voice could possibly be the original Demonic Announcer instead, as his voice is heard at the beginning of Grief.