Samantha Emilia Abigail Maxis was born to Ludvig Maxis and his unknown wife. After his wife died, Maxis made sure she was always close to him. Due to his research, however, he neglected her and failed to notice Richtofen's experiments on her. As the experiments went on, Richtofen grew to hate her, perhaps due to Maxis' attachment to her or due to what she had become. When Richtofen trapped Sam in the room with Fluffy and activated the teleporter, she was teleported to Griffin Station. Schuster and Groph then used her in the M.P.D. to control the zombies. Samantha, however, was unwilling to deal with them, so they found and brought Maxis to her. Maxis told her to kill them all and subsequently died, sending Samantha over the edge and on a rampage to destroy all of Group 935, which had betrayed Maxis. After Richtofen trades bodies with her to control the zombies, she and the super soldier test subjects activate Maxis's backup plan and incinerate the earth, leaving Richtofen trapped in her body and only able to control the Zombies on the Moon and the remaining Zombies on Earth.
In Samantha's demonic room in Kino der Toten, her room features a Teddy Bear and a Monkey Bomb. It also has a crude replica of Der Riese complete with miniatures of the original characters.