- "Shepherd is using Site Hotel Bravo. You know where it is. I'll see you in hell."
- — Vladimir Makarov to John Price in "The Enemy of My Enemy".
In Call of Duty: Modern Warfare 2, Captain John "Soap" MacTavish and Captain John Price infiltrate the base to kill Shepherd after Shepherd betrayed Task Force 141 and killed Roach and Ghost on the Georgian-Russian border while escaping with a DSM for him. The base security is initially unaware of the TF 141 operatives' presence until many of their men go missing. Once he realizes that the base is compromised, Shepherd orders the evacuation of the site and executes "Directive One-One-Six Bravo", destroying the base via explosives and a Danger Close artillery strike in an attempt to kill the two, while he escapes. Most of the base is destroyed but Soap and Price are unharmed. After escaping, the pair pursue Shepherd in a Zodiac, eventually shooting down his Pave Low, then killing him.
The base is under a civilian roadway, with a cave leading into a series of connected tunnels. The base contains a command center, an ammunition cache, a motor pool, and a utility room.
Site Hotel Bravo is located somewhere in Afghanistan and is first mentioned in "The Enemy of My Enemy" by Makarov after Price asks him where Shepherd is. The base appears in the levels "Just Like Old Times" and "Endgame".