In an interview with Polygon, Call of Duty: Infinite Warfare's narrative director, Taylor Kurosaki (formerly of Naughty Dog), stated that "We want to establish our own new sub-franchise. Our own new branch of the Call of Duty tree" when asked about Infinite Warfare's potential as a sub-franchise.
He went on talk about how Infinity Ward tried to craft "very rich world" that can be the basis of multiple games, going so far as to state that they're "not even close to exhausting" the lore of this new universe in the upcoming game. He also cryptically mentions that there are many new "under the hood" changes in the new game.
When asked about the story, he mention that it was "first and foremost a classic war story" that closely followed "in the great tradition of the genre." And for those of you that dislike the new science fiction setting of the most recent Call of Duty games, Kurosaki mention that the story of the game more closely followed a traditional military tale than a science fiction story; a story that's been "designed to tell a story of the burden of leadership."
Perhaps the most ambitious part of this interview is the fact that Kurosaki so openly advocating for a sequel, given the poor reception Infinite Warfare has received thus far and Ghosts's unresolved cliffhanger. Whatever the case may be, we'll have to wait until November to see if the changes made sway the nay-sayers or prove them right.