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Zürich is first featured in the mission "New World", where the Player, inside a simulation during surgery is tasked with preventing a terrorist attack on December 12th, 2054 from an unidentified terrorist cell. The Player is guided by Taylor, Diaz, Hall and Maretti during each segment of the simulation of Zürich. In the mission "Life", Hendricks launches a terrorist attack on the Coalescence Corporation Headquarters in downtown Zürich, taking control of Coalescence's robots around the entire city, causing chaos, death and destruction around the city.
In multiplayer, Metro takes place in Zürich.